Sulfobutyl Ether-beta-cyclodextrin Sodium Salt From Binzhou Zhiyuan

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Last update:
2017-12-22 06:34
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Company Profile

Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

By certification [File Integrity]

Contact: zbzhiyuanshengwu(Mr.)

Email:

Telephone:

Area: Shandong

Address: Shandong

Website: http://www.cydextrins.com/ http://zbzhiyuanshengwu.jxnhkj.com/

Product details

DMF No.: 030167

Name: sulfobutyl ether-beta-cyclodextrin sodium salt

Other name : betadex sulfobutyl ether sodium ; sulfobutyl ether-β-cyclodextrin sodium salt

CAS: 182410-00-0

Abbreviation: SBEBCD

Molecular formula : C₄₂H_70-nO₃₅ (C₄H₈O₃S Na)n

Molecular weight: 1135+158n

Solubility(in 100cm3 solvent, at 25℃) : water:>50g

Methanol:<0.5g

Acetone :<0.5g

Qaulity ： injection grade / oral grade

Standard : USP39

Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum , 20kg/drum or customized

Use : medical

Specification : USP39

ITEMS	SPECIFICATION	RESULTS
Appearance	White to off-white solid, free from foreign matter	Qualify
Solution Clarity	A 30%w/v solution in water is clear and essentially free from particles of foreign matter	Qualify
Identification (IR)	Consistent with SBECD standard	Qualify
Sodium Identification	Identify test are positive for Sodium	+
Average Degree of Substitution	6.2-6.9	6.7
SBE 1 Content	≤0.2%	0.05%
SBE 2 Content	≤0.8%	0.15%
Water solution pH	pH of 30%w/v solution in water is 4.0-6.8	5.4
Heavy Metals	≤5ppm	<5ppm
Water	≤10%	4.0%
β-Cyclodextrin Content	≤0.1%	Absence
Sodium Chloride	≤0.2%	0.01%
1,4-butane sultone	≤0.5ppm	0.3ppm
4-Hydroxybutane-1-Sulfonic Acid	≤0.09%	0.01%
Disodium bis-(4-sulfobtyl) ether	≤0.05%	0.05%
Assay	95%-105%	99.5%
Bacterial endotoxins	≤25EU/g	≤20EU/g
Microbiology
Total viable aerobic count (mould plus yeast)	≤100CFU/g	20CFU/g
Escherichia Coli	Absence	Absence
Salmonella species	Absence	Absence
mould plus yeast	≤50CFU/g	Absence

Features and applications:

SBE-β-CD is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability, solubility and safety, reducing drug toxicity and hemolysis, covering up bad smell, and controlling drug release rate.

SBE-β-CD has been used in injection, oral, nasal and eye medication. Modification by charged functional units can improve the binding affinity of cyclodextrins for oppositely charged guests, so it has a special affinity for drugs with nitrogen elements.

If you're looking for the high-quality sulfobutyl ether-beta-cyclodextrin sodium salt, our company must be your best choice. We're one of the leading manufacturers and supplier with rich experience and wide expertise. Please be rest assured to buy the products from our factory.